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Both sides managed to progress after seeing off Porto and Borussia Dortmund respectively, but with just three and four days recovery, Thomas Tuchel and Pep Guardiola will have to change things around in this one.
However, both these sides have a case to make that they have the best squads in England, with the likes of Raheem Sterling, Gabriel Jesus, Timo Werner and Olivier Giroud able to come into the fold.
This one could well be won from the bench when players begin to become leggy and substitutes are able to make their mark, so that is something to look out for if the game remains tight into the closing stages.
Here is everything you need to know about the game.
When is it?
The match will kick off at 5:30pm GMT on Saturday, April 17.
How can I watch it?
The fixture will air live on available to watch live on BBC One. Those with a TV licence will also be able to stream the match on BBC iPlayer.
Chelsea: Kepa; Rudiger, Silva, Azpilicueta; James, Kante, Jorginho, Chilwell; Ziyech, Mount, Werner
Man City: Steffen, Cancelo, Dias, Laporte, Mendy, Rodrigo, Fernandinho, De Bruyne, Torres, Sterling, Jesus
Chelsea - 15/4
Draw - 13/5
Man City - 3/4
Chelsea will likely shape up in a similar way to how they did in the second leg against Porto, sitting off Man City and trying to keep things as tight as possible. Pep Guardiola’s side will undoubtedly have the majority of the ball and try to suffocate the game away from Thomas Tuchel’s men. And you have to say that it will almost certainly pay off. 0-2 Man City.