The Cardinals signed tight end Blake Whiteheart to the active roster from the practice squad Tuesday, the team announced.
Whiteheart, an undrafted rookie, has never played a regular-season game.
Tight end Zach Ertz officially went on injured reserve in a corresponding move. He will miss the next four games before becoming eligible to return.
Ertz, 32, strained a quadriceps Sunday.
He has 27 catches for 187 yards with a touchdown this season.
The team also announced it has released safety K'Von Wallace and cornerback Quavian White from the practice squad.