The Arizona Cardinals will open the 2022 regular season at home against the Kansas City Chiefs. It is a huge afternoon matchup between Cardinals QB Kyler Murray and Chiefs QB Patrick Mahomes.
The Chiefs have been to the playoffs seven straight seasons and have made it to the Super Bowl twice with Mahomes as their starter, winning one title.
The Cardinals made the postseason last season for the first time since 2015 and hope to return. They have improved each season with Murray as their starter and Kliff Kingsbury as their head coach.
The Cardinals open the season as home underdogs vs. the Chiefs. Let’s have a look at the Week 1 odds and lines for this Week 1 matchup, according to Tipico Sportsbook.
Chiefs at Cardinals Week 1 odds and lines
Chiefs -200 (Bet $200 to win $100)
Cardinals +165 (Bet $100 to win $165)
Betting on the money line — the outright winner, a $200 wager on the Chiefs would win $100 profit. A $100 bet on the Cardinals to win the game outright would net $165 in winnings.
The Chiefs were 14-6 straight up last season and the Cardinals were 11-7, with postseason games included for both teams.
Chiefs -4.5 (-105)
Cardinals +4.5 (-115)
A $105 ATS bet on the Chiefs pays out $100 if they beat the Cardinals by 5 or more points.
A $115 bet on the Cardinals to win against the spread would pay out $100 profit if they win the game outright, tie or lost by no more than 4 points.
Including the postseason, the Chiefs were 10-10 ATS, while the Cardinals were 10-8 ATS.
Over 53.5 (-115)
Under 53.5 (-105)
A $115 bet on the Over wins $100 if the two teams combine for 54 or more points, while a $105 wager on the Under nets $100 if they combine for 53 or fewer.
The Chiefs were 12-8 O/U last season, while the Cardinals were 8-10 O/U.
Chiefs vs. Cardinals history
The Cardinals and chiefs have faced each other 13 times. The Chiefs lead the all-time series 9-3-1.
The two teams last played in Kansas City in 2018. The Chiefs picked up a 26-14 win that weekend.
The Cardinals have only beaten the Chiefs once in their last five matchups.
Mahomes is 1-0 against the Cardinals in his career. Murray will face the Chiefs for the first time.
Mahomes is 4-0 as a starter in season openers. Murray is 2-0-1.