Greece's Antetokounmpo, who earned his first All-Star nod last season, received 863,416 votes to edge the Cleveland Cavaliers' four-time NBA Most Valuable Player LeBron James (856,080) by 7,336 votes for the top spot in the Eastern Conference and overall after the first 12 days of fan voting.
Antetokounmpo, 23, has enjoyed a stellar start to the 2017-18 campaign. He is the league's second in scoring, averaging 29.1 points per game, and ranks in the top 20 in blocks, steals and rebounds.
The 67th NBA All-Star Game will take place on Sunday, February 18 at Staples Center in Los Angeles.
Under a new All-Star Game format that replaces the traditional matchup between the Eastern Conference and the Western Conference, the team rosters will be chosen by two captains from the pool of starters and reserves.
The captains will be the All-Star starter from each conference who receives the most fan votes in his conference, but they can choose their players without respect to conference affiliation.
The All-Star Game starters will be revealed on January 18.
For the second consecutive year, NBA players and basketball media will join fans in selecting the starters.
Fan balloting accounts for 50 percent of the vote, while all current players and a media panel will account for 25 percent each.