Bryant has a thigh injury and Hand has a groin injury.
Detroit also elevated defensive tackle Frank Herron and wide receiver Mohamed Sanu from the practice squad to the active/inactive list.
There's a lengthy list of players on both teams with injury concerns heading into this game. Running back Christian McCaffrey is out for the Panthers, and each team's quarterback - Detroit's Matthew Stafford and Carolina's Teddy Bridgewater - is questionable.
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