Tom Brady led the Tampa Bay Buccaneers to a comfortable NFL win, while the Green Bay Packers and Seattle Seahawks stayed unbeaten.
Brady's Bucs were largely untroubled by the Denver Broncos as they claimed a second straight win on Sunday.
Meanwhile, Russell Wilson made history for the red-hot Seattle Seahawks, who overcame the Dallas Cowboys.
Like Seattle, the Packers are 3-0 after holding off the New Orleans Saints.
BRADY LIFTS BUCCANEERS AFTER STRONG START
Brady threw three touchdown passes in the first half as the Buccaneers enjoyed a 28-10 win over the Broncos.
The six-time Super Bowl champion finished the game with 297 yards after completing 25 of 38 passes.
Brady threw two TD passes to Mike Evans in the second quarter, having found Chris Godwin with a 10-yard pass in the first.
"He [Evans] is a great red-area threat, and I think his size, his quickness, his elusiveness, his hands – everything," the QB said.
"Mike is one of the great receivers in the NFL so I've got to find ways to get him the ball and get him into space, not just in the red area but all over the field. It's my job to find the guys that are open and get it to them."
The Buccaneers are 2-1 and top of the NFC South.
SEAHAWKS, PACKERS STAY PERFECT
Wilson starred again as the Seahawks edged the Cowboys 38-31.
The quarterback threw five touchdown passes, including 315 yards on the back of 27 of 40 completed passes.
Wilson's 14 TD passes through the first three weeks of an NFL season are a record, eclipsing Kansas City Chiefs star Patrick Mahomes' 13 to begin 2018.
Aaron Rodgers and the Packers were too strong for the Saints 37-30.
Alvin Kamara brought the Saints level late in the third quarter after an incredible run following a pass from Drew Brees (completed 29 of 36 passes for 288 yards and three TDs).
But the Packers closed out victory in the fourth quarter, with Rodgers (21 of 32 for 283 yards and three TDs) and Robert Tonyan combining for a crucial TD.
LIONS HAND CARDINALS FIRST LOSS, JETS SLIP TO 0-3
Kyler Murray and the Arizona Cardinals fell to their first loss of the season, beaten by the Detroit Lions 26-23.
Murray, the top pick in the 2019 NFL Draft, had a difficult outing, intercepted three times. He finished 23 of 35 for 270 yards and two TDs.
Matt Prater kicked two fourth-quarter field goals for the Lions, including a 39-yarder as time expired.
The New York Jets fell to 0-3 after suffering a 36-7 loss to the Indianapolis Colts.
The Carolina Panthers recorded their first win of the season thanks to a 21-16 success over the Los Angeles Chargers.
Week 3 scores:
Chicago Bears 30-26 Atlanta Falcons
Buffalo Bills 35-32 Los Angeles Rams
Cleveland Browns 34-20 Washington Football Team
Tennessee Titans 31-30 Minnesota Vikings
New England Patriots 36-20 Las Vegas Raiders
San Francisco 49ers 36-9 New York Giants
Philadelphia Eagles 23-23 Cincinnati Bengals
Pittsburgh Steelers 28-21 Houston Texans
Indianapolis Colts 36-7 New York Jets
Carolina Panthers 21-16 Los Angeles Chargers
Detroit Lions 26-23 Arizona Cardinals
Tampa Bay Buccaneers 28-10 Denver Broncos
Seattle Seahawks 38-31 Dallas Cowboys
Green Bay Packers 37-30 New Orleans Saints