The New York Giants are 0-3 and must go on the road to face the 3-0 Kansas City Chiefs. They’ll be doing so without at least two-fifths — and maybe three-fifths — of their offensive line.
Center David Baas and right guard Chris Snee are officially out for the game. In addition, right tackle David Diehl is listed as doubtful with a thumb injury.
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The Giants have allowed 11 sacks this season, but seven came last week (and six in the first 17 minutes of play) against the Carolina Panthers. The Chiefs have an NFL-best 15 sacks, including six last week.
Left tackle William Beatty, who has struggled to pass block, will have to deal with Chiefs pass rusher Tamba Hali much of the game. Rookie right tackle Justin Pugh, who also has taken some serious lumps, must try to stop the Chiefs’ Justin Houston, the NFL’s leader in sacks with 7.5. No indication who will start in Baas’ place at center and have to content with nose tackle Dontari Poe, who is off to a great start.
Oh, and the Giants also will be without cornerback Corey Webster, who has been ruled out, too. Other than that, they are in great shape.
The Chiefs, meanwhile, tight end Travis Kelce (knee) is out again, and five regular contributors are listed as questionable: guard Jeff Allen (groin), tight end Anthony Fasano (ankle/knee), corner Brandon Flowers (knee), and safety Kendrick Lewis (ankle).
Now onto the rest of the significant injuries for Sunday’s games:
Baltimore Ravens at Buffalo Bills: Ray Rice (hip) is listed as questionable but is likely to go in this one, barring any setbacks. But the team's depth will be tested with a slew of contributors listed as questionable or doubtful. Good news, Bills fans: Safety Jairus Byrd is listed as questionable, which is an improvement, although so are defensive end Mario Williams (ankle) and running back C.J. Spiller (quad).
Cincinnati Bengals at Cleveland Browns: Brian Hoyer once more will start at quarterback for Brandon Weeden (thumb), who is out. Jabaal Sheard (knee) is listed as doubtful, which could hurt that talented front seven. The Bengals are suffering from a hamstring epidemic in the secondary: Leon Hall, Dre Kirkpatrick and Reggie Nelson all are listed at doubtful, so perhaps Hoyer can have another big game throwing the ball.
Chicago Bears at Detroit Lions: It sounds as if Bears corner Charles Tillman (groin/knee) will be a go, which sets up a great battle against the Lions' passing game. Henry Melton is done for the season with a torn ACL, leaving the Bears' D-line a bit thin. For the Lions, receiver Nate Burleson (forearm) is out, and four are questionable, including defensive end Ziggy Ansah (abdomen) and right tackle Jason Fox (groin). Fox practiced fully Friday; Ansah practiced on a limited basis.
Seattle Seahawks at Houston Texans: The Seahawks will be painfully thin up front if center Max Unger (arm) and right tackle Breno Giacomini (knee), both doubtful, can't go with left tackle Russell Okung already on injured reserve. J.J Watt has to be licking his lips if they all are out. The Texans have a slew of players listed as questionable — left tackle Duane Brown (toe), cornerbacks Kareem Jackson (illness) and Johnathan Joseph (toe), receiver Andre Johnson (shin) and linebacker Darryl Sharpton (hip/foot) — who have a chance to play.
Indianapolis Colts at Jacksonville Jaguars: The surprise is that Colts running back Ahmad Bradshaw, who apparently suffered a neck injury during his breakout game at San Francisco, and will be out for this one. That sets up a big workload in the perfect setting for new running back Trent Richardson. Safety LaRon Landry also is out. Blaine Gabbert is back to starting for the Jaguars at quarterback, and most of the team's core will be available, too.
Pittsburgh Steelers at Minnesota Vikings (in London): We very well could see the NFL debut of Steelers rookie running back Le'Veon Bell, who is listed as probable and likely would start. But just as the Steelers are getting healthier, the Vikings are banged up. With Christian Ponder (rib) out, Matt Cassel will get his first start with the team. Also out: corner Chris Cook (groin), tight end Rhett Ellison (knee) and safety Jamarca Sanford (hamstring).
Arizona Cardinals at Tampa Bay Buccaneers: Two Cardinals defenders, nose tackle Dan Williams (personal) and linebacker Kevin Minter (hamstring), have been ruled out. Rashad Johnson, who lost part of his finger in last week's loss, could play — he's questionable — but would wear a club-like cast on his hand if he does. Wow. New Buccaneers starting quarterback Mike Glennon is hoping that his two main receivers, Vincent Jackson (rib) and Mike Williams (hamstring), can go; both are listed as questionable.
New York Jets at Tennessee Titans: With Chris Ivory (hamstring) out, Bilal Powell should start at running back for the Jets and could be poised for a nice game. Also out is corner Dee Milliner (hamstring), who had been off to a tough start this season. Titans receiver Kenny Britt (neck/ribs) is listed as questionable.
Philadelphia Eagles at Denver Broncos: The Eagles come in healthy, with only harried safety Patrick Chung ruled out; only one other player — left tackle Jason Peters — made the list, and he's probable. Corner Champ Bailey (foot) is listed questionable and very well could make his season debut, but safety Duke Ihenacho (ankle) might be on the outside looking in.
Washington Redskins at Oakland Raiders: The big question is Terrelle Pryor — the Raiders' quarterback suffered a concussion against the Broncos on Monday, and though he practiced Friday, there still is doubt if he can go. Otherwise, welcome Matt Flynn to the lineup. The Redskins will have most hands on deck, but tight end Fred Davis (ankle) is one of five players at questionable.
Dallas Cowboys at San Diego Chargers: Miles Austin's hamstring issues, which have been going on a few seasons now, continue as he's been ruled out. It appears that Dwayne Harris, despite a hip injury (questionable), could take his spot in the lineup as the slot receiver. Expect Chargers rookie linebacker Manti Te'o to make his season debut after missing the first three games with a pesky foot injury.
New England Patriots at Atlanta Falcons: Steven Jackson (hip) is out for at least another week, and once again receivers Roddy White (ankle) and Julio Jones (knee) are questionable, though both have played through pain to date. Joining them at the 50-50 mark are cornerback Asante Samuel (thigh) and left tackle Sam Baker (knee/foot). There are reports that Patriots tight end Rob Gronkowski will miss yet another game, but could Danny Amendola (groin) return? Stay tuned; it likely will be a Sunday decision.