Spread Options: Dr. Saturday’s Week 10 picks against the spread

The train has left the station. Are you on board?

Back-to-back 7-3 weeks have the season's picks to a nice 49-42-1. Just like last week, the College GameDay matchup of Miami at Florida State has a massive spread as the 'Noles are 21 point favorites. And just like last week, we're staying away from that game.

Let's do it to it.

USC at Oregon State (-4), 9 p.m. ET FRIDAY: That loss to Eastern Washington in week one is a big afterthought for the Beavers. USC struggled on offense at Notre Dame, but took care of Utah easily. The road woes continue. Chalk this one up to a bounceback game for Oregon State after last week's loss to Stanford.

Northern Illinois at UMass (Over 58.5), Noon ET: Northern Illinois is in full-on Jordan Lynch for Heisman mode -- he caught a touchdown pass last week -- so if the Huskies jump out to a big lead, don't expect them to pack it in. The fewest points NIU has given up this season is 17; every other opponent has scored over 20, and only two of its games have ended with a lower point total than 58.

West Virginia at TCU (OVER 45.5), 3:30 p.m. ET: The loser of this game must win out for bowl eligibility while the winner is one game away from .500. TCU is favored by 12.5 which seems about right, but Casey Pachall is back for the Horned Frogs and West Virginia has the capability of scoring over 20. Given how up and down they've been, it's far from a guarantee, but we like their chances.

Minnesota (+8) at Indiana, 3:30 p.m. ET: Here's college football for you. A team with back-to-back wins over Northwestern and Nebraska is more than a touchdown underdog against a team that's 3-4. Indiana's defense is bad, bad, bad, so we like the Gophers' chances of winning this game outright.

Georgia (-3) vs. Florida, 3:30 p.m. ET: We won't make a training room joke here, but the return of Todd Gurley puts this one squarely in the Bulldogs' favor. The Florida offense may actually be able to move the ball on Georgia's defense, but Aaron Murray and company take this by a touchdown.

Clemson (-17.5) at Virginia, 3:30 p.m. ET: Yes, I realize that it's hard to trust Clemson, but Virginia is reeling. This is the Cavaliers' third straight home game, and the preceding two games were double digit losses to Duke and Georgia Tech. Clemson is significantly better than those two teams. Yes, there's a Clemsoning watch in effect, but there's a much bigger chance it'll be a blowout.

Arizona (-16) at Cal, 3:30 p.m. ET: I promise I'm not picking on you, Cal. It's nothing personal. Since losing to Northwestern by 14 points in the season opener and then winning its second game of the season, Cal has lost six straight games, all by more than 16 points. Arizona is sneaky good at 5-2 and just beat Colorado by 24 on the road.

Tulane (+2) at Florida Atlantic, 5 p.m. ET: Run, run, run on this one before it's taken off the board. (Legally, of course) The Green Wave is 4-0 in the conference and FAU is 2-6 coming off of a tumultuous week that included the resignation of coach Carl Pelini and defensive coordinator Pete Rekstis. While it's natural not to buy in all the way on Tulane, don't worry about that this week.

Auburn (-7.5) at Arkansas, 5 p.m. ET: This is a prove it game of sorts for the Tigers. A convincing win shows that the win at Texas A&M wasn't a fluke. Anything less of one against an Arkansas team that has struggled, especially throwing the football, dampers the expectations. And a loss derails any hope of a monumental Iron Bowl that serves as a SEC West championship. Tigers roll.

Oklahoma State at Texas Tech (-1), 7 p.m. ET: Oklahoma State is a flawed teamm though you can say the same thing about Texas Tech. The Cowboys have beaten the Red Raiders by a combined 98 points the past two seasons, but OSU isn't as good as it was the last two years. Tech is better than it's been the last two years. It's Blackout and a night game in Lubbock. Take Tech.

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Nick Bromberg is the assistant editor of Dr. Saturday on Yahoo Sports. Have a tip? Email him at nickbromberg@yahoo.com or follow him on Twitter!