One Thing to Know: Harbaugh calls out Seahawks

The 49ers and Seahawks have a pretty serious rivalry brewing, thanks in no small part to the distaste their coaches share for one another. Jim Harbaugh, who had a testy encounter with Pete Carroll in 2011, fired a couple more shots in the Seahawks' direction this week. In reference to Seattle's numerous suspensions for performance enhancing drugs this offseason, Harbaugh said, "If you have to cheat to win the game, you've already lost."