It's rare that we begin an Injury Wrap with a defensive player, but the rules are different for Darrelle Revis, the premier cover corner in the NFL.
Revis suffered a concussion in Week 1's victory over the Bills, and on Friday he was ruled out for Sunday's Week 2 game at Pittsburgh. The loss of Revis isn't something that can be measured in a singular way: his absence potentially changes the design of the Jets game plan and secondary play. When Revis is active and on his game, he essentially buys you an extra defender to play with. With Revis on the sidelines, Antonio Cromartie will have to play more isolated coverage and the exploitable Kyle Wilson becomes a full-time corner.
If you were concerned about starting Antonio Brown and Mike Wallace this week, free the shackles. I'm not suggesting Ben Roethlisberger is going to post pinball stats on game day — the remainder of the Jets defense is solid — but Revis's scratch is a game-changer and a rank-changer.
In other high-relevance Friday injury news:
• Ryan Mathews (clavicle) had a limited practice Friday and is listed as questionable for Sunday's late kickoff with Tennessee. Given all the uncertainty tied to this situation — we don't know if Mathews can go or how much work he could possibly take on — I wouldn't put lofty expectations on the Chargers back this week. San Diego's backfield is a mess after Mathews, so there's no clear handcuff worth speculating on. On my clipboard, this has "Wait until Week 3" written all over it. (Friend of Yahoo! Michael Gehlken, now a Chargers beat writer, speculates that Mathews will not dress on Sunday. That's good enough for me.)
• Pierre Garcon (foot) has been tabbed a game-time decision for Sunday's match at St. Louis. It's a late start, unfortunately, so it throws a wrench into our fake-football game planning. I'm not going to tinker with Robert Griffin's rank — albeit Garcon is his top target — but if I knew for sure Garcon were scratched, I'd be tempted to dial up Aldrick Robinson as a sleeper play. Robinson had a sneaky four-catch, 52-yard effort in Week 1, with a touchdown.
• Andy Reid is optimistic that DeSean Jackson (hamstring) and Jeremy Maclin (hip) will be able to play against Baltimore, though their status won't be nailed down until Sunday. When you factor in the opponent and Michael Vick's shaky Week 1 start, I'm not eager to deploy any of the Philly passing options. Jason Avant is the No. 3 wideout in Philadelphia, a pro but an unexciting option for standard leagues. (I do need Avant in one of my 20-team leagues, but that's no concern of yours. Let's move along.)
• Although Hakeem Nicks (foot) had a limited practice week, the Giants are expecting him to go against the Bucs. Nicks was clearly compromised by the foot problem in the opener, and he didn't do much in training camp. I'm still going to rank him as a plausible starter for most fantasy teams, but it will probably be in the 18-24 range. We'll have updated Yahoo! Staff Rankings Friday evening.
Now that the headline news is out of the way, settle in for the full report (in the usual QB-RB-WR-TE order):
• Jake Locker (shoulder) had a full practice Friday, which means he's a good bet to start Sunday at San Diego. The Titans are listing him as questionable, perhaps Mike Munchak's way of messing with the opponent.
• Jonathan Dwyer (foot) had two full days of practice to close the week out, setting him up to get a decent chunk of action Sunday against the Jets. Rashard Mendenhall (doubtful/knee) doesn't appear ready yet, and Isaac Redman didn't show anything in the loss to Denver.
• Marshawn Lynch (back) is listed as probable, so he should be good to go for the home opener against Dallas. Hopefully he'll have his top blocker, LT Russell Okung, in the lineup as well. Okung (knee) is listed as questionable, though he completed a full practice Friday.
• Arian Foster (illness/back) is listed as probable, which means he's expected to go at Jacksonville. The Texans didn't seem worried about Foster's condition last week: they were handing him goal-line touches in the fourth quarter even with the game completely out of hand.
• Jonathan Stewart (ankle) had two full days of practice before Friday's partial day. Although he's listed as questionable, context clues point to him dressing against the Saints. It's an early start, so we'll have clarity to the situation before the primary wave hits.
• Adrian Peterson (knee) is listed as probable, not that anyone is in a position to doubt him after his miraculous debut last week. Dial him up at Indianapolis.
• Daniel Thomas (post concussion) won't dress for Miami's home opener, so Reggie Bush could be headed for a busy day against the Raiders.
• Trent Richardson (knee) is probable, and should be used early and often at Cincinnati. Can his struggling line open any holes for him?
• Carolina's Steve Smith (knee) is listed as questionable, though every comment from Panthers camp indicates he'll be on the field against New Orleans. It's a critical game between a couple of desperate 0-1 clubs.
• Calvin Johnson (probable/foot) was handled carefully this week, standard operating procedure for the Lions. They don't take chances with their meal ticket. Megatron is fully expected to go Sunday night against the Niners.
• Devery Henderson (post concussion) won't play in Week 2, which protects Lance Moore's snap count. Moore was utilized in a modest 42 percent of the New Orleans snaps last year; he saw action 75 percent of the time in the opener.
• Nate Washington (leg) missed the full practice week, so his questionable tag sounds overly optimistic. Find a safer option. Kenny Britt (knee) is ready to make his 2012 debut, though he's expected to be on a snap count, something in the 15-25 range.
• Austin Collie (concussion) is listed as doubtful for Indy's home opener against Minnesota. You need to keep expectations grounded on any player dealing with repeated concussion problems. Donnie Avery and T.Y. Hilton move up the depth chart if Collie can't play.
• Golden Tate (knee) might be ready to start for Seattle, which would likely push Braylon Edwards back to a complimentary role. Sidney Rice (probable/knee) is also dinged up.
• Although Denarius Moore (hamstring) is listed as probable, he'll likely be on a snap count at Miami. You should have safer options.
• Antonio Gates (questionable/ribs) took some reps Friday after missing the two previous days. It sounds like he'll go, but have a caddy ready, just in case.
• Dustin Keller (hamstring) won't dress at Pittsburgh, which means Mark Sanchez will have to focus on his outside targets. The Jets don't have a second pass-catching tight end of note, and their backs are rarely utilized in the passing game.
• Sebastian Janikowski (groin) is listed as probable. Might as well double-check his status on Sunday, just in case.
• Brad Evans is not on the injury report, and he had time to produce the helpful Fantasy Minute video you'll find below. Good luck in Week 2, gamers.