Kessel, who also scored the overtime winner against Edmonton on Tuesday, became the 18th American-born player to reach 300 career goals and the second active behind Minnesota's Zach Parise.
Kessel stripped Patrik Laine of the puck at his own blue line and went the other way on a breakaway. Kessel, with nine points in his last seven games, snapped a wrist shot between the pads of Jets goalie Connor Hellebuyck for the winner.
Conor Sheary scored his fifth for the Penguins, who won for the fifth time in six games. Pittsburgh has won seven of nine since losing the first two games of the season.
Pittsburgh also won its 17th straight home game against the Jets dating back to March 24, 2007. Overall, Pittsburgh won 17 of the last 20 meetings against the Jets, who last won in Pittsburgh, Dec. 27, 2006, when they were the Atlanta Thrashers.
Matt Murray won his seventh straight since allowing 11 goals on 65 shots in his first two appearances. Murray, who stopped 30 shots, helped Pittsburgh earn points in all eight starts this season (see full recap).
Vrbata's 7th career hat trick sparks Panthers' rout
SUNRISE, Fla. -- Radim Vrbata recorded his seventh career hat trick to lift the Florida Panthers to an 8-3 victory over the Anaheim Ducks on Thursday night.
Evegenii Dadanov scored two goals and Vincent Trocheck and Aleksander Barkov each had a goal and two assists for the Panthers while Owen Tippett, the youngest player in the NHL at 18, scored his first career goal. James Reimer made 31 saves. Thirteen players recorded points for the Panthers.
Kalle Kossila scored his first NHL goal for Anaheim and Andrew Cogliano and Logan Shaw also scored. John Gibson allowed six goals on 17 shots in two periods. Gibson was replaced by Reto Berra to start the third period. Berra stopped three shots.
Vrbata's third goal came off a rebound and gave the Panthers a 7-2 lead at 8:39 of the third. Vrbata's seven hat tricks are with five different teams. The last one was Dec. 7, 2015 for the Vancouver Canucks against the Buffalo Sabres.
Dadanov's second goal made the score 8-3 with 2:41 left.
The Panthers scored six goals on their first 15 shots (see full recap).
Buchnevich, Nieves help Rangers keep Coyotes winless
NEW YORK -- Pavel Buchnevich scored twice and added an assist, rookie Boo Nieves had three assists and the New York Rangers beat the winless Arizona Coyotes 5-2 Thursday night.
Michael Grabner had two goals, Chris Kreider also scored and Ondrej Pavelec stopped 27 shots to help the Rangers get just their third victory of the season in the finale of a season-high six-game homestand.
New York shook up its line combinations and played with a traditional lineup consisting of 12 forwards and six defensemen for the first time in a week. It helped the Rangers beat Arizona for the eighth straight time, dating back to March 24, 2014.
Anthony Duclair and Clayton Keller scored, and Adin Hill made 24 saves as the Coyotes fell to 0-9-1. The loss spoiled the return of former Rangers star Derek Stepan to Madison Square Garden for the first time since he was traded to Arizona along with goalie Antti Raanta in the offseason (see full recap).