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The 28-year-old American is expected to undergo surgery after suffering a gruesome leg injury in a 37-36 win over the Atlanta Falcons.
"If I've learned anything from before it's not a time for self-pity and negativity," he tweeted Sunday night.
Eifert fractured his ankle after catching a pass then landing awkwardly on his right leg when he was tackled by Atlanta's De'Vondre Campbell in the third quarter. Eifert's lower leg was pointed in a sideways angle making it immediately evident that this was a serious injury.
He was put on a stretcher then carted off the field to the medical room. With tears in his eyes, Eifert waved to the crowd.
"Having this happen crushes me," Eifert said. "The only thing to do is move forward with optimism."
Because of various injuries, Eifert has played in just 14 games over the past three seasons.
In the 2015 Pro Bowl game he injured his ankle. He has undergone several back surgeries which ended his 2016 and 2017 seasons. He also missed all of the 2014 season after injuring his elbow in the season opener.