Agnew was limited in practice Friday and had been questionable to play because of a knee injury that kept him out of last week's 23-17 loss to the New York Giants.
Agnew also has seven receptions and two touchdowns this season as a wide receiver.
For Denver, second-year safety Caden Sterns (hip) was placed on injured reserve on Friday.
The Broncos' inactive players are CB Essang Bassey (hamstring), OLB Baron Browning (hip), WR Tyrie Cleveland (groin), T Cam Fleming (quad), as well as RB Marlon Mack, TE Albert Okwuegbunam and DL Eyioma Uwazurike.
Denver promoted RB Devine Ozigbo from the practice squad to the 53-man roster and elevated OLB Jonathan Kongbo and T Quinn Bailey.
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