Each week, NBC Sports Bay Area 49ers insider Matt Maiocco will preview the upcoming matchup and key storylines heading into Sunday's game for 49ers.com. For more takeaways and features from Maiocco, visit NBCSportsBayArea.com.
General manager John Lynch and the 49ers personnel department worked hard the past three-plus years to build a roster rich with talent and depth.
So, as the 49ers enter Week 2 of the 2020 season, how would this team fare if it did not have the services of its most irreplaceable players on each side of the ball?
Just wait until Sunday – and perhaps the following week, too. That's when we will all find out.
Kittle is the heartbeat of the offense. And the all-knowing Sherman is the conscience of the defense.
Neither player will be available when the 49ers take the field Sunday to face the New York Jets at MetLife Stadium in East Rutherford, New Jersey.