49ers-Cardinals odds, predictions: Betting lines, picks for NFL Week 16 game

NBC Sports Bay Area Staff
·1 min read

49ers-Cardinals predictions: Can SF pull off NFC West upset? originally appeared on NBC Sports Bayarea

Saturday will be a tale of two different quarterbacks for the 49ers and Arizona Cardinals. While the Cardinals will have former No. 1 pick Kyler Murray on their side, San Francisco will send out its third QB of the year in C.J. Beathard. 

But there's good news for Beathard. 

Star tight end George Kittle is expected to play Saturday after missing the past six games due to a fractured cuboid bone in his foot. Unfortunately for defensive coordinator Robert Saleh, cornerback Richard Sherman already has been ruled out.

RELATED: Barnwell proposes intriguing 49ers-Pats Jimmy G trade

Here's how the experts see a game of division rivals playing out.

Line: Cardinals -4

Odds provided by our partner, PointsBet.


Josh Schrock, NBC Sports Bay Area: Cardinals 31, 49ers 23

Nick Wagoner, ESPN: Cardinals 27, 49ers 20

Josh Weinfuss, ESPN: Cardinals 37, 49ers 24

Matt Barrows: Cardinals 27, 49ers 17

Mike Florio, ProFootballTalk: Cardinals 30, 49ers 23

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