San Francisco faces a difficult midseason road in their quest to repeat its 13-3 record, which led to an NFC West championship and home-field advantage throughout the NFC playoffs.
Beginning in Week 6 and stretching through Week 13, the 49ers are scheduled to face five teams that qualified for the playoffs in 2019.
During that time, the 49ers also have two games against the Los Angeles Rams, who would have made the playoffs if the NFL's newly adopted playoff format with seven teams per conference would have taken effect a year earlier.
In Week 6, the 49ers play the Rams at Levi's Stadium on Oct. 18 in a Sunday night game. Then, the 49ers have back-to-back road games at the Tom Brady-less New England Patriots (Oct. 25) and the Seattle Seahawks (Nov. 1).
The 49ers have a quick turnaround on Thursday night against the Green Bay Packers at Levi's Stadium on Nov. 5 in a rematch of the NFC Championship Game. Running back Raheem Mostert rushed for 220 yards and four touchdowns in the team's 37-20 victory over Green Bay to advance to Super Bowl LIV.
Then, the 49ers will be back in action 10 days later (Nov. 15) with a return trip to New Orleans, where the 49ers and Saints squared off last season in an epic showdown. Both teams provided all kinds of fireworks last season, as Jimmy Garoppolo and George Kittle rallied the 49ers to a memorable 48-46 victory.
After the bye in Week 11, the 49ers travel to face the Rams for the second time in six weeks.
The 49ers make their only appearance on "Monday Night Football" in Week 13 with a game at Levi's Stadium on Dec. 7 against the Buffalo Bills.
On paper, the 49ers' easiest stretch of the season comes in the opening three weeks, but two of those games are on the road.
In Weeks 2 and 3, the 49ers theoretically will have the option of remaining on the East Coast with back-to-back games scheduled at MetLife Stadium in East Rutherford, New Jersey. The 49ers face newly signed Frank Gore and the New York Jets on Sept. 20, then are back in the same location to meet the New York Giants on Sept. 27.
The 49ers face the rising Arizona Cardinals to open the season on Sept. 13 at Levi's Stadium. The second meeting between the clubs is scheduled for Week 16, either Saturday or Sunday, Dec. 26 or 27, in Arizona.
Coach Kyle Shanahan's team is scheduled for five prime-time games after a season in which they blew a 10-point fourth-quarter lead in a 31-20 loss to the Kansas City Chiefs in Super Bowl LIV.
The 49ers' only night road game will come in Week 15, when they face the Dallas Cowboys at 5:20 p.m. on NBC's "Sunday Night Football."
The 49ers wrap up the season, as they did last season, against the Seahawks. However, this time the finale will be played at Levi's Stadium.
49ers' 2020 schedule features midseason stretch packed with contenders originally appeared on NBC Sports Bay Area