Love had 24 points and 13 rebounds while James weighed in with 23 points, seven rebounds and six assists as the Cavs improved to 17-7.
Cleveland can equal their franchise record for consecutive victories if they beat Sacramento at home on Wednesday.
Chicago however were left reflecting on a ninth straight loss which has seen them slip to 3-19.
Kris Dunn was their top-scorer with 15 points on a night when the home team got little change from the visiting Cavaliers.
Holiday sank a buzzer beater to reduce the Cavaliers lead to 86-71 heading into the final quarter, but Cleveland upped the scoring pace to cruise home.