Sabres coach Lindy Ruff (300-266-84) became the 31st NHL coach to win 300 games, and 16th to do so with the same team.
Briere’s winner came on the power play after Brian Pothier hooked Afinogenov to prevent a clearcut breakaway. Alone at the right post, Afinogenov set up the decisive goal when he fed a pass through the crease to a wide-open Briere, who jammed it in the open side.
The goal capped a big night for Briere, who tied the game, scoring with 39 seconds left in regulation.
Brian Campbell set up the tying goal when he avoided two diving Ottawa defenders and, from the left circle, set up Briere open to the right of the net.
Kelly had given the Senators the lead only five minutes earlier off a turnover, beating Sabres goalie Martin Biron with a shot from the right circle.
Buffalo improved to 2-5 against the Eastern Conference-leading Senators— the other Buffalo win coming in a shootout.
The Senators lost for the first time in 54 games when scoring four or more goals, ending the third-longest streak in NHL history. The streak dates to a 5-4 overtime loss to Toronto on Feb. 5, 2003.
The Sabres responded after Schubert, with a short-handed goal, and Eaves, on the power play, scored 50 seconds apart to give Ottawa a 3-1 lead 5:18 into the second period.
Roy, with a nifty deke that pulled Ottawa’s Ray Emery out of position, scored 21 seconds later. Fitzpatrick then tied the game midway through the period when his snap shot from the point banked in off the left post.
Senators C Mike Fisher had an assist, returning to the lineup after missing nine games with a sprained right ankle. Ottawa demoted LW Denis Hamel to AHL Binghamton. … The Senators were without four defensemen, including Wade Redden, who missed his fourth straight games, excused for personal reasons. … Sabres G Martin Biron assisted on Afinogenov’s goal. It was Biron’s his first of the season, fifth of his career and second against the Senators.