Ottawa, which went 39-27-9-7 last season, is unbeaten in its last eight home games (7-0-1) and has not suffered a regulation loss in its last 12 home games (10-0-1-1).
Overall, the Senators are 6-1-1 since losing their final three games before the All-Star break. They have allowed just 13 goals and have recorded a pair of shutouts in that stretch.
Ottawa is six points ahead of New Jersey for first place in the Eastern Conference and comes off a 5-3 road win over the Devils on Wednesday.
Hossa’s 38 goals are a career high and are tied for the league lead with Vancouver’s Markus Naslund.
Martin Havlat also tallied twice Wednesday before leaving midway through the third period with what initially was diagnosed as a leg injury. Both of his goals were set up by Shaun Van Allen, who tied a career high with four assists.
Florida snapped a four-game winless streak (0-2-1-1) with a 3-0 shutout over Montreal on Tuesday in the opener of a three-game road trip. Roberto Luongo made 24 saves for his sixth shutout of the season and Olli Jokinen and Viktor Kozlov each had a goal and an assist.
Jokinen continued his breakout season by extending his points streak to six games, while Kozlov scored for the fourth time in five games.
Ottawa is 8-1-0 in its last nine meetings with Florida.