Montreal completed a 2-1-0-1 homestand with a 3-0 loss to the Florida Panthers on Tuesday.
The Canadiens lost in regulation for the first time in their last five games (4-1-0-1) following a season-high four-game losing streak.
Montreal has lost three of its last four road games and is 10-14-3-3 away from the Air Canada Centre.
The Canadiens continue to play without defenseman Patrice Brisebois, who is sidelined indefinitely with an irregular heartbeat.
Montreal is 5-6-0-0 this season in the second game of back-to-backs.
Buffalo has just one win in its last 10 games (1-6-0-3) and skated to a 4-3 overtime loss in Atlanta on Monday.
Buffalo has lost three of its last four home games and is just 10-13-4-1 here this season.