Detroit comes off a 5-3 loss at Colorado on Saturday and is 0-4-2 since a 5-2 victory at Vancouver on January 24.
All-Star Brett Hull has gone seven games without a goal as he continues his quest for his 700th career tally.
While Hull has been cold, Detroit star Sergei Fedorov has been hot, at coach Dave Lewis. Fedorov complained about a lack of ice time after playing only 14:59 on Saturday.
Fedorov is averaging just under 21 minutes per game to lead the Red Wings, but has played over 20 minutes in only three of the last 10 games.
Detroit is just 2-5-2-1 in its last 10 games and trails St. Louis by five points for the lead in the Central Division.
San Jose has lost three of its last four games and has dropped the first two contests on its two-week, seven-game road trip.
The Red Wings have excelled against the Sharks, winning six of their last eight meetings. Detroit earned 6-3 and 3-2 victories over San Jose in October.
San Jose has won just twice in 22 games here, with the last coming on December 20, 2000.
Sharks center Mark Smith, who has not scored a goal in 86 games, is on a career-high three-game points streak. Smith has eight assists this season, all of which have come since December 21.