Pittsburgh has lost three straight games and is just 1-5-1 in its last seven contests.
On Tuesday, the Penguins lost to Vancouver, 3-2. Alexei Kovalev, who has been the subject of trade rumors, scored both goals for Pittsburgh.
Florida also has gone just 1-5-1 in its last seven games. On Wednesday, the Panthers were embarrassed at home by Toronto, 6-0.
Roberto Luongo was pulled just 1:46 into the second period after allowing a third goal. Jani Hurme finished the contest and gave up another three goals on 11 shots. Florida went 0-of-4 on the power play.
The Panthers defeated the Penguins twice in Florida, 4-3 in overtime on November 6 and, 3-0, on January 18.
Pittsburgh went 1-0-1 at home against Florida last season.