The Sabres are unbeaten in their last seven games (5-0-2) and have lost just once in 10 games following a seven-game losing streak. It is their longest unbeaten streak since an eight-game run from November 29-December 18, 1998.
Buffalo has not allowed a goal in three straight games, cruising to a 4-0 victory over the Toronto Maple Leafs on Friday.
Buffalo is unbeaten in its last four games on the road (3-0-1) to improve to 9-10-4-1 away from HSBC Arena.
Ottawa has lost just once in its last eight games, skating to a 3-3 tie against the Atlanta Thrashers on Thursday.
Ottawa has won its last three home games to improve to 17-4-1-1 at the Corel Centre this season.
The Senators have won the first three meetings with the Sabres this season after losing the previous seven games between the teams.