| Player | Date | Status | Injury |
|---|---|---|---|
| Brooks Foster | Sep 2, 2009 | Injured Reserve | Ankle |
| Adam Carriker | Sep 5, 2009 | Injured Reserve | Shoulder |
| Eric Bassey | Sep 6, 2009 | Injured Reserve | Knee |
| Laurent Robinson | Sep 30, 2009 | Injured Reserve | Fibula |
| Gary Gibson | Oct 12, 2009 | Injured Reserve | Foot/ankle |
| Chris Massey | Oct 26, 2009 | Injured Reserve | Knee |
| Bradley Fletcher | Oct 28, 2009 | Injured Reserve | Right knee |
| Clifton Ryan | Oct 30, 2009 | Probable | Illness |
| Justin King | Oct 30, 2009 | Probable | Groin |
| James Hall | Oct 30, 2009 | Probable | Groin |
| Donnie Avery | Oct 30, 2009 | Probable | Shoulder |
| C.J. Ah You | Oct 30, 2009 | Questionable | Ankle |
| Richie Incognito | Oct 30, 2009 | Out | Foot |
| Date | Player | Position | Transaction |
|---|---|---|---|
| Nov 3 | Danny Gorrer | RCB | Signed by St. Louis |
| Nov 3 | Tim Carter | WR | Cut by St. Louis |
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| Team | W | L | T | PF | PA |
|---|---|---|---|---|---|
| Arizona | 4 | 3 | 0 | 157 | 143 |
| San Francisco | 3 | 4 | 0 | 147 | 140 |
| Seattle | 2 | 5 | 0 | 135 | 147 |
| St. Louis | 1 | 7 | 0 | 77 | 221 |
| Preseason | ||
|---|---|---|
| Week | Date | Opponent |
| Fri 8/14 | New York Jets at NY Jets | W 23 - 20 |
| Fri 8/21 | Atlanta Falcons Atlanta | L 13 - 20 |
| Thu 8/27 | Cincinnati Bengals at Cincinnati | W 24 - 21 |
| Thu 9/3 | Kansas City Chiefs Kansas City | W 17 - 9 |
| Regular Season | ||
|---|---|---|
| Week | Date | Opponent |
| Sun 9/13 | Seattle Seahawks at Seattle | L 0 - 28 |
| Sun 9/20 | Washington Redskins at Washington | L 7 - 9 |
| Sun 9/27 | Green Bay Packers Green Bay | L 17 - 36 |
| Sun 10/4 | San Francisco 49ers at San Francisco | L 0 - 35 |
| Sun 10/11 | Minnesota Vikings Minnesota | L 10 - 38 |
| Sun 10/18 | Jacksonville Jaguars at Jacksonville | L 20 - 23 |
| Sun 10/25 | Indianapolis Colts Indianapolis | L 6 - 42 |
| Sun 11/1 | Detroit Lions at Detroit | W 17 - 10 |
| Bye | ||
| Sun 11/15 | New Orleans Saints New Orleans | 1:00 pm |
| Sun 11/22 | Arizona Cardinals Arizona | 4:05 pm |
| Sun 11/29 | Seattle Seahawks Seattle | 1:00 pm |
| Sun 12/6 | Chicago Bears at Chicago | 1:00 pm |
| Sun 12/13 | Tennessee Titans at Tennessee | 1:00 pm |
| Sun 12/20 | Houston Texans Houston | 1:00 pm |
| Sun 12/27 | Arizona Cardinals at Arizona | 4:05 pm |
| Sun 1/3 | San Francisco 49ers San Francisco | 1:00 pm |
| Stat | Player | Total |
|---|---|---|
| PasYds | Marc Bulger | 956 |
| RusYds | Steven Jackson | 784 |
| Rec | Keenan Burton | 25 |
| RecYds | Donnie Avery | 286 |
| TD | Daniel Fells | 3 |
| Sack | Leonard Little | 5.0 |
| Int | James Laurinaitis | 2 |