AFC North Champions 12-4 (6-2 road) No. 2 seed
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| Away | Expert | Home | Reason |
| Pittsburgh | Jason Cole | As tempting as it is to pick the Cardinals, it's hard to go against Pittsburgh's defense. As fast as Arizona quarterback Kurt Warner is with the ball, the Steelers are just as fast getting there. | |
| Michael Silver | Arizona | After rolling with the Cardinals as underdogs three times in these playoffs, did you really think I'd give up on them before the biggest game of all? That's right, I'm changing my pick: Arizona over Pittsburgh on a Warner to Boldin TD pass. | |
| Pittsburgh | James C. Black | I've been picking against the Cardinals all postseason, so why change now? Pittsburgh will find a way to consistently harass Kurt Warner, and Larry Fitzgerald will have a much harder time getting open. | |
| Pittsburgh | Charles Robinson | The Cardinals haven't faced an elite pass rush like Pittsburgh's. The Steelers have an adept ability to shut down the run, then destroy timing with the blitz and create the kind of hurried passes that translate into turnovers. |