But it wasn't all about the Mannings.
Knowshon Moreno rushed for a pair of touchdowns and Trindon Holliday found pay dirt on a backbreaking 81-yard punt return in the fourth quarter as the Broncos defeated the Giants, 41-23. Unfortunately, there were very few highlights for the G-Men, who turned the ball over four times and failed to capitalize on scoring opportunities for the second week in row.
Let's take a look at the winners and losers from Big Blue's second loss of the season:
RB David Wilson -- Wilson only rushed for 17 yards on seven carries, but at least he didn't fumble, like he did twice against the Dallas Cowboys in Week 1. Moreover, he showed improvement at picking up the blitz, one of his biggest weaknesses. It's something to build on for the second-year pro, who still could have the breakout season many fans envisioned for him coming into this year.
CB Terrell Thomas -- Thomas, who defended Wes Welker, had his second strong game in a row. He held the speedy slot receiver to 39 yards on three catches, although one of them was a two-yard touchdown in the third quarter. After a two-year absence due to ACL injuries, Thomas has become a vital part of the team's improved secondary, as his surgically repaired knee has held up to the demands of playing cornerback.
[Related: Eli Manning, Giants have some major problems]
RB Brandon Jacobs -- Jacobs, who sat out most of last season after joining the San Francisco 49ers, scored a touchdown in his return to the Giants. The big man's one-yard dive in the third quarter made it 17-16 and was his first TD for New York since the divisional round of the 2011 playoffs. With more practice and conditioning, perhaps Jacobs can become a key member of the team's backfield.
QB Eli Manning -- Aside from losing to his older brother for the third time in three games, the younger Manning thossed four interceptions, including a costly one with the Giants in field-goal range before halftime. He finished 28-of-49 passing with 362 yards and one touchdown. Not all of them have been his fault, but Manning has seven interceptions through the first two games of the season.
[Related: NFL's Week 2 winners and losers]
TE Brandon Myers -- Myers had six catches for 74 yards, but he made a couple of costly mistakes in the second quarter. First, he stumbled and fell on his own inside Denver's 20-yard line after making a 27-yard catch down the middle. Later in the drive, Myers had a pass slip between his hands at the one-yard line, which at the very least would have been a first down. The Giants settled for a field goal.
WR Rueben Randle -- Randle made a costly mistake in the first quarter when he fumbled the ball into the end zone on what should have been a touchdown. The Broncos recovered the ball, but a penalty negated the turnover and the Giants eventually settled for three points. After having five catches for 101 yards last week, Randle finished with three grabs on nine targets for 14 yards against Denver.
Adam Martini is a freelance sports writer with more than 15 years of experience covering amateur and professional sports for several print and online media outlets. He tracked the New York Giants for Yahoo! Contributor Network during the team's Super Bowl run in 2011-12. Adam can be found on Twitter @Pegcitysports.
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- Brandon Jacobs