Nicks was limited at practice on Friday and was listed as questionable for the game. The fifth-year wide receiver has 42 catches for 620 yards, but he has not caught a touchdown.
Rueben Randle, who leads the Giants with six touchdown catches, replaced him in the starting lineup.
The Cowboys had no surprises among their inactives as linebackers Sean Lee, Justin Durant and DeVonte Holloman were ruled out on Friday.
AP NFL website: www.pro32.ap.org
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