The visiting White Sox look to extend their season-high winning streak to five games by keeping Joe Blanton winless and handing the Angels a fourth consecutive defeat Saturday.
Chicago (19-21) dropped five of seven before Chris Sale one-hit Los Angeles to salvage one victory during a three-game home set Sunday. The White Sox lost 10-3 the next night at Minnesota, but since have won four in a row, including the first two in Anaheim.
The Angels (15-27), meanwhile, have lost three straight and five of six since winning three in a row.
Sale allowed three hits and struck out 12 over 7 2-3 innings and Alex Rios homered for the second straight game in Chicago's 3-0 win at Los Angeles on Friday. The 24-year-old ace has gone 23 innings without yielding a run.
"A team like (the Angels), they've got some amazing ballplayers," Sale said. "So you've got to make adjustments.
"It's never easy facing a team in back-to-back starts."
Rios is batting .388 with four home runs and nine RBIs during a 12-game hitting streak. He's hit .350 (7 for 20) with three RBIs this season versus Los Angeles.
Teammate Adam Dunn homered for the fourth time in four games Friday. The slugger is 7 for 16 (.438) with eight RBIs during the stretch that followed a four-game span which he went 0 for 14.
Chicago looks to stay hot against Blanton (0-7, 6.46 ERA), who will try a ninth time to earn his first win as an Angel.
The right-hander allowed a season-high seven runs and 12 hits while striking out seven without a walk in 4 2-3 innings of an 11-4 loss to Kansas City on Monday. It marked the first time in franchise history that the Angels have lost each of a pitcher's first eight starts in a season.
"Joe had a rough outing, to say the least,'' Angels manager Mike Scioscia said. "We'll turn the page on it, and hopefully he'll get where he needs to be in his next start."
Blanton is 3-1 with a 2.59 ERA against the White Sox, but has not faced them since 2008 with Oakland.
Chicago counters with Hector Santiago (1-2, 2.33), who allowed a solo homer in 12 1-3 innings to go 1-0 in his first two starts after replacing the injured Gavin Floyd, but gave up six - three earned - in 5 2-3 frames Monday.
With injured starter John Danks apparently close to returning to the rotation, Santiago could drop out. With a 3-1 record and 1.93 ERA in seven career starts, Santiago also has heard his name in trade rumors.
"I kind of try not to think about it, but you always have something in the back of your mind," he told the White Sox's official website about his uncertain future.
In his only previous appearance against the Angels, Santiago threw 2-3 scoreless innings of relief on Sept. 21.
Los Angeles' Mike Trout is 0 for 6 in the series after he hit .368 with six homers and 17 RBIs in the previous 15 contests.
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