TORONTO -- Dayan Viciedo's ninth-inning RBI double coupled with a Hector Gimenez sacrifice fly helped the Chicago White Sox edge the Toronto Blue Jays 4-3 on Tuesday night.
After walks to Adam Dunn and Paul Konerko put runners on first and second, Vicideo lined a Steve Delabar pitch over the head of Emilio Bonifacio in center field, allowing DeWayne Wise to score from second and give Chicago a 3-2 lead.
The White Sox (6-8) added to its lead later in the inning when Gimenez's sacrifice fly scored Konerko from third.
Delabar (1-1) picked up his first loss of the season. Matt Lindstrom (1-0), who pitched a third of an inning, picked up the win and Addison Reed his fifth save of the season.
Chicago improved to 2-6 on a 10-game road trip.
In the bottom of the ninth, Edwin Encarnacion scored from third on a Brett Lawrie sacrifice fly, pulling the Blue Jays to 4-3, but that's as close as Toronto would get.
The Blue Jays (6-8) dropped two games below .500 after entering the game winners of three of their last four games.
Lawrie, who had been out of the Jays lineup since suffering a rib injury on March 6 during a World Baseball Classic tuneup game, showed he was fully recovered with a defensive gem in the top of the eighth.
With two out, Lawrie charged the infield on an Alex Rios grounder and threw out the former Blue Jay in typical high-energy Lawrie fashion.
J.P. Arencibia gave Toronto its first lead the night with a home run off Dylan Axelrod, his fifth homer of the season and second in as many nights in the bottom of the sixth.
Axelrod (0-1) finished the night throwing 94 pitches in six innings, surrendering two earned runs and seven hits while striking out four.
Toronto's lead was short-lived, however, as Konerko took Josh Johnson deep to left field in the top of the seventh to tie it 2-2.
White Sox third baseman Conor Gillaspie, who came into Tuesday's game 12 for 28 and hitting .429 in his past eight games, followed Konerko trying to add to the offense but was robbed of a sure single by Blue Jays shortstop Munenori Kawasaki, who made an excellent diving grab behind second base.
Gillaspie finished 0 for 3 with a walk and a strikeout.
Johnson (0-1) went seven innings, allowing two earned runs and four hits while striking out eight. He threw 109 pitches in his longest outing of the season. Johnson became the first Blue Jays starter to complete seven innings this season.
With the Blue Jays trailing 1-0 in the bottom of the second, Colby Rasmus took Axelrod's 1-and-2 offering deep to center field off the second deck for his fourth home run of the season.
Chicago opened the scoring in the top of the second when Konerko scored from third on a Johnson wild pitch.
After striking out Dunn to lead off the second, Johnson allowed two singles and a walk to load the bases. Then with two out, Johnson uncorked a wild pitch, allowing Konerko to score from third. Johnson managed to limit the damage, striking out Gimenez for the final out of the inning to end the threat.
Through five, Johnson has allowed one run and three hits while striking out six. Johnson was coming off the shortest start of his career after pitching 1 1/3 innings on April 11 in a loss at Detroit.
NOTES: Blue Jays right fielder Jose Bautista missed his second straight game with a sore back. Manager John Gibbons revealed Tuesday that Bautista is also suffering from an inner-ear infection. ... Toronto right-hander Jeremy Jeffress was outrighted by the Blue Jays on Tuesday. General Manager Alex Anthopoulos said Jeffress would go to extended spring training and then likely to triple-A Buffalo. ... According to Anthopoulos, left-hander Ricky Romero threw a simulated game on Tuesday in Dunedin, Fla., but there is no timeline for him to return to game action. ... Lawrie, who missed the first 13 games of the season with a rib injury, returned to the lineup Tuesday. ... White Sox infielder Gordon Beckham underwent surgery to repair his fractured left hand and will require six weeks of recovery time. ... Chicago left-hander John Danks threw six innings in extended spring training in Arizona on Monday night and is scheduled to pitch again Saturday. ... For a second straight night, both teams observed a moment of silence to pay respect to the victims of Monday's Boston Marathon bombings.