CHICAGO -- Chris Sale showed again Wednesday night why he's the best pitcher on the Chicago White Sox, striking out 13 while scattering three hits and allowing just one walk in 7 2/3 innings as the White Sox completed a three-game sweep of the New York Yankees, 2-1.
Alex Rios' solo home run into the left-center field stands in the bottom of the sixth broke a 1-1 tie and the White Sox would never look back, earning their first three-game sweep of the Yankees at U.S. Cellular Field since 1991, the same year the replacement to fabled Comiskey Park opened.
Sale improved to 15-4, and Addison Reed got his 23rd save.
Yankees starter Phil Hughes (12-11) took the loss. Hughes allowed two earned runs on five hits, walked two and struck out in seven innings.
Sale handcuffed the Yankees in the first five innings, allowing just two hits, a double to Mark Teixeira in the top of the second and another double to Robinson Cano in the fourth. Both batters were unable to advance.
Hughes looked almost as strong as Sale, scattering just four hits in the first five innings. However, the big difference between the two starting pitchers was that Hughes allowed a run in the third inning.
Gordon Beckham led off with a double to right-center field, advanced to third on a bunt single by Yankees castoff Dewayne Wise, and scored on Kevin Youkilis' sacrifice fly.
The Yankees tied the game in the sixth when Derek Jeter hit his 13th home run of the season and his third of the series. But Chicago came right back in the bottom of the sixth when Rios slammed his 20th homer of the season for what proved to be the game-winning run.
The Yankees lead the majors with 193 home runs, the most in club history through 123 games, and are on pace to hit 253 homers, which would break the team record of 244, set in 2009. The MLB record is 264 by the 1997 Seattle Mariners.
The Yankees' Ichiro Suzuki failed to hit safely for only the third time in his 25 starts with New York since being acquired from Seattle on July 23.
In other Yankees news, pitcher Ivan Nova, who struggled in Tuesday night's loss, will likely miss at least his next turn in the rotation, according to MLB.com.
Nova complained of stiffness in his right shoulder, according to the report, and will return to New York to have his arm examined by team physician Dr. Christopher Ahmad. Nova said he felt "something tight in my shoulder" when he threw the last few fastballs during his six-inning stint Tuesday.
"This was the first time I've experienced that," Nova added. "I'm always worried about my arm. I need to be 100 percent. With any kind of injury, you've got to feel concerned about it."
But Yankees manager Joe Girardi doesn't seem overly concerned: "We don't really think it's a big thing, but we want to make sure," Girardi said. "Obviously, we don't think he's going to make his next start. The DL will be determined on what the doctor says. Short term, there's a little concern, but I don't think it's anything serious."
Girardi said right-hander David Phelps will likely take Nova's next scheduled start.
NOTES: Even with a battle between two divisional leaders, only 26,319 fans attended Wednesday's game. .... Finally, after 20 consecutive games without a day off, the Yankees get a breather Thursday off. They play in Cleveland this weekend, and manager Joe Girardi said CC Sabathia will be activated from the DL and start Friday. ... Even though they return to New York after that, the Yankees shouldn't unpack their luggage just yet: They will play 13 of their next 19 games away from Yankee Stadium.