USC (18-12, 11-7 Pac-12) led 56-48 with 4 1/2 minutes remaining but Colorado capped an 11-2 run with a three-point play by Brittany Wilson to take a 59-58 lead with 1:21 left.
Crook then made a pair of free throws to give USC a one-point lead with 56 seconds left and Colorado (16-13, 6-12) missed a layup on each of its next two possessions as the Trojans finished their regular season with two consecutive victories.
In a game of runs, Colorado trailed 34-22 at halftime but opened the second half on a 14-2 run to tie the game. USC responded with an 11-2 run to take a 47-38 lead with 11:11 left.
Brittany Wilson had 15 points for Colorado, which missed all nine of its 3-point attempts and hit just 9 of 21 free throws.
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