He hasn't been nearly as successful against the Minnesota Twins, though.
Chicago seeks a split of its four-game set with visiting Minnesota behind Quintana on Sunday.
After averaging 1.8 runs during a 10-game losing streak, the last-place White Sox (44-71) have won four of six on their 10-game homestand.
They swept the New York Yankees earlier this week before holding on for a 5-4 win over the Twins on Saturday, as Jordan Danks homered in the second inning and Conor Gillaspie singled home the go-ahead run in the sixth.
The White Sox hadn't won four times in a six-game span since June 5-10.
''A win is a win. It doesn't matter how you do it,'' said closer Addison Reed, who picked up his 28th save. "Hopefully, it gets a little spark in us and starts a little winning streak.''
Chicago's stretch began when Quintana (6-3, 3.51 ERA) allowed one run in 6 2-3 innings of Monday's 8-1 win over the Yankees. He improved to 3-1 with a 2.58 ERA over his last seven starts and finally got help from his offense.
"That was nice to get good run support," said Quintana, who had been given just six runs in his last four starts. "I tried to think the game was 0-0."
The left-hander didn't fare well last season in three starts versus the Twins, going 0-1 with a 9.20 ERA. He gave up seven runs in just 1 1-3 innings of an 18-9 defeat Sept. 4 the last time he faced them.
Josh Willingham is 5 for 6 with two homers versus Quintana and Justin Morneau is 4 for 7.
Morneau homered again Sunday for the Twins (51-63) after hitting a pair, including a grand slam, Friday in a 7-5 win in the first game of a doubleheader. Oswaldo Arcia, who has gone deep in each of this series' three games, homered in the 10th inning of a 3-2 win in the nightcap and nearly hit a second on Saturday but flied out to the wall for the final out.
Willingham came off the disabled list following knee surgery for this series and has gone 2 for 13 as the designated hitter.
''Getting swings right now is more important and running the bases,'' manager Ron Gardenhire said. ''He's already played the outfield down (in the minors during rehab), so I'm not worried about that.''
The Twins, who have won eight of 11 against the White Sox this season, look to get help from starter Kevin Correia (7-8, 4.84) as he seeks to bounce back from a rough outing.
Minnesota has lost seven of Correia's last eight starts since he allowed two runs in 6 2-3 innings of a 7-4 win over the White Sox on June 19. He gave up six runs in two innings of Monday's 13-0 loss to Kansas City, marking the second time in three outings he gave up six runs and lasted fewer than three innings.
"I was just not able to get anybody out," Correia said. "I just didn't have good command of my stuff.''
The right-hander's only other career start versus Chicago came May 14, when he allowed four runs in seven innings of a 4-2 defeat.
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