Damian Lillard added 23 points and 10 assists for the Blazers, who are still playing without injured All-Star LaMarcus Aldridge. Portland (45-24) remained in fifth place in the Western Conference with three victories in their last four games after a four-game losing streak.
The Wizards (35-33) have lost two straight to open four-game swing against the Western Conference while they vie for a playoff spot in the East to end a five-year absence.
John Wall had 24 points and 14 assists for Washington, which trailed by as many as 17 points in the second half.
Wizards center Marcin Gortat was scratched from the lineup just before the game because of a lower back strain. It was the first game he's missed this season.
Gortat, who hurt his back during pregame warmups and left the court wincing, is averaging 12.8 points and 9.3 rebounds per game. In Washington's 117-111 overtime loss at Sacramento on Tuesday, Gortat had 19 points and 14 rebounds.
The Wizards started the Kevin Seraphin in his place.
The Wizards are still without forward Nene, who missed his 12th gram because of a sprained left MCL.
The Blazers played without Aldridge for the fourth straight game because of a lower back contusion. He is expected to return when the Blazers play at Charlotte on Saturday.
They got a scare against the Wizards when reserve guard Will Barton, who has been a spark off the bench this season, appeared to injure his right arm and left the game for a time. In the second half he wore a brace on his elbow.
The Blazers jumped out to a 19-14 lead, but the Wizards answered with a 14-4 run to lead 28-23 after the first quarter. Bradley Beal's layup extended the lead to 35-27.
The Wizards stayed in front, going up 45-39 on former Blazer Martell Webster's dunk.
But Lillard dunked with less than a minute to go in the half and Robin Lopez added a layup to tie the game at 51. Lillard added a pair of free throws for a 53-51 Blazers lead at the break.
Portland opened the third quarter with an 11-3 run, including 3-pointers from Lillard, Dorell Wright and Matthews, to stretch the lead to 64-53. The Blazers had six 3s in the quarter to head into the final period with an 86-73 lead.
Barton's pass between the legs of Drew Gooden was snagged by Thomas Robinson for the jam to make it 89-73.
Wright, who has been starting in Aldridge's absence, matched his season-high with 15 points.
Gooden had 18 points and nine rebounds off the bench for Washington.
Portland got off to a slow start but eventually defeated Milwaukee 120-115 in overtime on Tuesday. Portland had lost five of their last six games going into the victory.
Notes: The Blazers on Thursday announced a $16 million makeover of the Moda Center, including renovation of the arena's suites and a new glass enclosed bar on the upper level that will offer a panoramic view of Portland. The Blazers are also holding a fan contest to redesign the team's court. ... The Blazers have had four straight games with at least 12 3-pointers, a franchise record
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- Portland Trail Blazers
- Washington Wizards
- Damian Lillard