Tennessee Titans starting quarterback Jake Locker left Sunday's game against the Jacksonville Jaguars in the second quarter with a right foot injury.
The Tennessean reported that Locker's injury appears to be a season-ending Lisfranc injury, although he will undergo further tests to confirm that preliminary diagnosis.
Locker was replaced by Ryan Fitzpatrick, who made two starts in Locker's place earlier this season when he had a hip injury.
The Titans were down 13-0 when Locker left the game. Before that, he threw an interception and lost a fumble.
Locker returned to the sideline later in the second half in a walking boot and on crutches.