DETROIT -- Torii Hunter lined an RBI single to left center field with one out in the 12th inning on Sunday to give the Detroit Tigers their eighth straight victory, a 3-2 win that sent the Chicago White Sox to their 10th straight loss.
Miguel Cabrera, in the process of sitting out a fourth straight game because of an abdominal strain, pinch-hit to lead off the 12th inning and grounded a single up the middle.
Matt Tuiasosopo pinch-ran for Cabrera and slumping Austin Jackson sacrificed him to second before Hunter lined a 2-0 pitch to left center to drive in the winning run against Dylan Axelrod (3-8).
Rookie Bruce Rondon (1-1) pitched the last two innings for Detroit, allowing one hit, to pick up the win.
The White Sox have now lost nine walk-off games this season.
Drew Smyly got the Tigers out of a jam in the eighth but began the ninth by giving up a tying leadoff home run to Paul Konerko, making it 2-2.
The White Sox muffed an opportunity to tie the score in the eighth after Alejandro De Aza doubled to lead off the inning. He was sacrificed to third but made the mistake of heading home on Alex Rios' liner to center and had to go back to tag up, which prevented him from scoring. Smyly came on to strike out Adam Dunn to end the threat.
Another goof on the bases hurt Chicago in the 10th when Tyler Flowers was doubled off second with one out on a liner that Jhonny Peralta caught over the shoulder while racing into shallow left.
Rookie Andre Rienzo (0-1) stymied Detroit for six innings in his second major league start, but he walked the first two batters in the seventh and set up the Tigers for two runs and a 2-1 lead.
Alex Avila lofted an RBI double to right center to tie the score and reliever Nate Jones got Jose Iglesias on a grounder to short that kept the status quo. But Ramon Santiago lined a sacrifice fly to center to bring in the go-ahead run for the Tigers.
Dunn's long home run into the second tier of shrubbery in center, his 26th homer of the season, had given Chicago a 1-0 lead in the fourth.
NOTES: Detroit activated LHP Darin Downs (left shoulder) from a rehab assignment and optioned him to Triple-A Toledo, for whom he had been pitching. ... Paul Konerko was Chicago's DH, switching with Dunn, after playing first base on Saturday night for the first time since coming off the disabled list on July 21. Manager Robin Ventura didn't want to play him in the field for a day game after a night game, marking his return to defense. ... Chicago rookie C Josh Phegley, 4-for-33 with one RBI in his previous 11 games, was given a rest Sunday with Tyler Flowers behind the plate.