Manager Mark Hughes confirmed that Shea, who picked up a knee injury in Stoke's 2-0 victory over Philadelphia Union on Tuesday, will definitely not be fit in time for the fixture.
However, the Welshman initially feared that Shea may be out for longer than the "number of weeks" he is now likely to miss.
"It's not as bad as we first feared which is great news for us, but we will still be without him for a number of weeks," Hughes told the club's official website.
"He certainly won't be available for the first game of the season against Liverpool, but the medical staff here are excellent and we can expect him to be back sooner than people think given the nature of the injury."
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