South Carolina-Upstate center Babatunde Olumuyiwa's short-range bucket with 1:52 left broke a tie and delivered a 64-63 win over host Virginia Tech in the season opener for both teams Saturday.
Olumuyiwa finished with nine points and five rebounds.
The Spartans (1-0) won their first game ever against an Atlantic Coast Conference team in eight tries.
Guard Ty Green scored 15 of his 17 points in the second half and forward Torrey Craig added 13 points for the Spartans. Forward Ricardo Glenn was the only other Spartan in double figures with 10 points.
Only two Hokies (0-1) scored in double figures, led by forward Jarell Eddie's 18 points. Forward Cadarian Rains scored all 17 of his points in the second half.
Only thee of Eddie's points came in the second half. Olumuyiwa blocked his desperation shot in the closing seconds.
The game was tied eight times in the second half before Olumuyiwa's basket made it 64-62.
The Spartans then fouled Eddie, who made one of two from the foul line with 1:29 left.
Neither team shot particularly well. The winning Spartans shot just 37.5 from the floor while the Hokies made 39 percent of their baskets.
Rebounding was even as both teams pulled down 39 boards. Spartans forward Jodd Maxey had a game-high 10 rebounds.
Free-throw shooting hurt Virginia Tech the most as it made just nine of 18 attempts from the line.
South Carolina-Upstate was a little better, making 11 of 16 from the foul line.