Tom Brady might have sustained a broken nose at Tennessee, but he didn't miss any plays.
Skelton won the Cardinals' starting job in the preseason, just as Locker did in Tennessee. But Skelton was sidelined with what coach Ken Whisenhunt called a sprained right ankle in the fourth quarter of a 20-16 win over Seattle.
Locker also went out in the final period, leaving a 34-13 loss to New England with a left shoulder problem after making a tackle.
Saffold had movement in his arms and legs after hurting his neck. He crumpled awkwardly after disengaging from Lions safety John Wendling on a long St. Louis touchdown pass. Coach Jeff Fisher said after the game Saffold would undergo a CT scan.
The 6-foot-5, 314-pound Saffold is in his third season with the Rams. He started nine games last season after starting 16 as a rookie.
Skelton was injured when the pocket collapsed around him and Seattle's Richard Sherman collided with another player into his leg. Skelton was down for several minutes before being loaded onto a cart and taken to the locker room.
Locker, a second-year quarterback in his first start, tried tackling Patriots safety Patrick Chung at the end of a 49-yard fumble return. The eighth pick overall in the 2011 draft walked to the sideline holding his left arm up against his body. But he quickly was throwing a ball on the sideline while veteran Matt Hasselbeck went into the game after officials overturned the original play as an incompletion. Locker tried to talk his way back onto the field.
''I felt like I could go back in, and I let them know that,'' Locker said. ''The medical staff made the decision they did.''
The Titans also lost receiver Nate Washington on that play, but Washington said afterward he was OK and didn't know if he had suffered a head injury.
Tennessee already had lost middle linebacker and defensive captain Colin McCarthy for the second half with a right ankle problem. He was on the sideline in a walking boot in the second half and not in uniform.
Brady was sacked by Kamerion Wimbley in the second quarter. Trainers taped up his nose, and he finished off the game by throwing for 236 yards and two touchdowns.
''I need some scars,'' Brady said, joking about the white bandage covering his nose and marring his usual look.
One replacement official, side judge Paul Caldera was tended to on a training table on the Detroit sideline, causing a brief delay before he was replaced on the crew by alternate Curtis Adams - a replacement for the replacement. Caldera hurt his left hamstring and eventually walked off the field.
Replacement officials were hired by the league while the regular officials are locked out and have been working games for the first time in 11 years.
Bills running back Fred Jackson injured his right leg when he was tackled hard by LaRon Landry. Jackson stayed down for a few moments while he was checked by trainers before walking on his own to the sideline. He walked around for a while before finally heading to the locker room, a towel draped over his head, with two trainers accompanying him.
Receiver David Nelson hurt a knee.
''Fred doesn't look as bad as David,'' coach Chan Gailey said. ''We don't know how bad David is, but it doesn't look good right now. We'll get a further evaluation (Monday).''
All-Pro cornerback Darrelle Revis left the Jets' 48-28 victory over Buffalo with a head injury. It doesn't appear Revis has a concussion, though.
The Jets' other starting CB, Antonio Cromartie, banged his left shoulder and had it wrapped after the game, but said he'll be fine. LB Bryan Thomas and WR Patrick Turner also left with hamstring injuries.
Indianapolis linebacker Dwight Freeney injured an ankle against the Bears and was scheduled for an MRI. Colts right tackle Winston Justice left the game with a concussion.
Chicago cornerback Charles Tillman also was hurt in the first quarter, limping off the field appearing to favor his right leg. He came back for the next defensive series, but sat out the rest of the game.
Texans LB Tim Dobbins left the win over Miami with a neck injury.
Several players went down in the Redskins' victory at New Orleans. Washington WR Pierre Garcon hurt his right foot after making four catches for 109 yards and a TD. Safety Jordan Bernstine hurt his right knee.
Saints cornerback Johnny Patrick hurt his right leg in the second quarter, WR Devery Henderson left in the second half after taking a shot to the head, and LB Scott Shanle sustained unspecified leg injury.
Atlanta CB Brent Grimes left in the fourth quarter of a win at Kansas City with a calf injury.
Lions rookie CB Bill Bentley left the win over St. Louis with a concussion.
Eagles safety Kurt Coleman's helmet went flying several yards as he tried to tackle Browns rookie RB Trent Richardson. After the Browns punted, Coleman spent several minutes being tended to on the bench by trainers, who worked on his face. Coleman had cuts on the bridge of his nose, upper lip and a swollen lower lip.
Browns CB Sheldon Brown left with a shoulder injury in the first quarter.
Broncos defensive tackle Ty Warren injured his elbow in his first game in three seasons. Warren had not played an NFL game since 2009 due to injury before taking the field Sunday night. The Broncos signed him as a free agent from New England before the 2011 season, but he missed the entire year after he suffered a torn triceps.
Pittsburgh offensive tackle Marcus Gilbert (left knee) and guard Ramon Foster (eye injury) also were hurt in the night game.
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