The Giallorossi already hold a victory over the Nerazzurri this season, a loss that was the Milan club's sole reverse on home ground this season.
Rudi Garcia's men turned in a stunning performance at San Siro back in October when they ran out 3-0 winners thanks to a double from talisman Francesco Totti and an Alessandro Florenzi strike - all scored in the first half.
Since then, Roma has been overtaken at the top by Juventus but sits second and is comfortably in the Champions League places.
If Roma completes a league double over Walter Mazzarri's side, it will move six points behind Juventus and, having lost just one league game all season, will feel it can mount a serious challenge to claim its first Scudetto since the 2000-01 season.
Roma will go into the game full of confidence, having won five of its last six games. Its recent record in games against Inter is very impressive: the club is unbeaten in five overall and has not tasted defeat at the Stadio Olimpico against Inter in four outings.
Even more daunting for the visitors is Roma's phenomenal home record this season. It has won 10 and drawn two of its 12 home outings in Serie A, conceding a paltry two goals and winning its last five.
Inter is on a three-match unbeaten run of its own but stuttered to a draw at home to struggling Cagliari last time out.
It leaves Mazzarri's men fifth in the table, five points behind Fiorentina in fourth, and they will need a win with Verona and Parma lurking just behind.
Recent away form does not make for pleasant reading for Inter fans. They have lost four of their previous five on the road in the league, although before that run, they had not tasted defeat on their travels all season.
Mazzarri will be heartened with the superb 2-1 win at Fiorentina in its last away game, though, and could have Hernanes back for the trip to Rome after the Brazilian midfielder missed out against Cagliari because of an injury.
For Garcia's men, Totti missed the win at Bologna through bruising, and this game may come too soon for Roma's captain, while Florenzi was taken off with a twisted ankle and is a doubt.
- Sports & Recreation
- Walter Mazzarri
- Francesco Totti
- Rudi Garcia