Rashad Green added 18 points and nine rebounds for the Dons (14-9, 4-5 West Coast), who won for the fourth time in five games. Cody Doolin added 14 points, 11 in the second half.
Denzel Johnson scored a season-high 26 points to lead the Broncos (8-12, 0-7), who lost their eighth straight to match their longest losing streak in 48 years.
Santa Clara played without leading scorer Kevin Foster, who missed his second game as a result of breaking team rules. Evan Rocquemore was held out of the starting lineup a second time for a different infraction.
The Dons held a 41-33 advantage at halftime as Green hit a 3-pointer at the buzzer.
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