The Sabres made the move before a deadline Friday that would have prevented Pysyk from playing in the minors during the 16-day break that begins Feb. 9.
Pysyk missed Buffalo's past two games with an undisclosed injury. He has a goal and five assists in 42 games this season.
To fill his spot, the Sabres recalled defenseman Chad Ruhwedel from Rochester.
Buffalo plays at Columbus on Saturday night.
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- Buffalo Sabres
- Mark Pysyk
- American Hockey League