The moves came a little over a week before Buffalo opens the season at Detroit Oct. 2.
McNabb and Ruhwedel were both regarded as contenders to make the Sabres roster.
With two preseason games left, the Sabres (3-1-1) are still carrying nine defensemen. It's a group that includes rookie first-round draft picks Rasmus Ristolainen and Nikita Zadorov.
Buffalo is also carrying 18 forwards and two goalies, Ryan Miller and Jhonas Enroth.
Teams have until Sept. 30 to set their 23-player rosters.
- Sports & Recreation
- Ice Hockey
- Buffalo Sabres
- Chad Ruhwedel
- Matt Ellis
- Mike Zigomanis