The Kansas City Royals had shown quite a knack for timely hitting before enduring an offensive hiccup Saturday.
Minnesota catcher Kurt Suzuki's red-hot run against the Royals saw no interruption.
Kansas City looks to rebound after just its third loss in 17 games and keep Suzuki at bay Sunday against the Twins.
The Royals (67-55) had averaged 5.3 runs while winning 11 of 12 but were 0 for 6 with runners in scoring position in a 4-1 defeat at Target Field on Saturday. Kansas City had been 39 for 99 (.394) in those situations in its previous 12 contests.
Lorenzo Cain struck out four times in as many at-bats and Salvador Perez was 0 for 4 from the lineup's No. 3 spot.
"When you only score one you don't give yourself a margin for error," said Billy Butler, who was 1 for 4 and left two men on base. "It's just one of those games where we couldn't get nothing going offensively."
The Twins (55-66) put together a three-run seventh inning after managing only one hit over the first six innings against Kansas City's Yordano Ventura.
Though Joe Mauer was 0 for 3 to halt his career best-matching hitting streak at 16 games, Suzuki was 2 for 3 with a home run. Suzuki is 14 for 28 with eight RBIs over his last nine matchups with the Royals and two of his three homers have come against them.
The eighth-year veteran is also 6 for 15 off Sunday's starter Jeremy Guthrie (8-10, 4.45 ERA) with three extra-base hits.
Guthrie is 3-4 with a 6.41 ERA over his last seven starts. He gave up a season worst-matching 11 hits along with six runs - four earned - over 4 2-3 innings of an 11-3 loss to Oakland on Tuesday.
But five days removed from a complete game, the right-hander didn't necessarily sound deterred.
"We play 162 of these and you take them for what it's worth," Guthrie said.
He has reason to be confident going into this outing given his 8-3 record and 2.94 ERA in 14 career games - 12 starts - against Minnesota. He'll be making his first appearance in the season series after going 4-1 with a 2.38 ERA in five matchups last year.
Guthrie is looking to win a third straight road start for the first time since July 28-Aug. 13, 2008, with Baltimore.
Tommy Milone (6-3, 3.52) makes his second start for the Twins since being traded by Oakland. He limited Houston to two runs in six innings in a 4-2 victory on Monday, though he wasn't credited with the win.
"Good to get the first one out of the way," Milone said. "Obviously going out there with a new team you want to pitch well and I felt like I did that."
He's 6-0 with a 2.65 ERA in his last 12 starts, marking the longest undefeated streak of his career. He's also 3-1 with a 1.84 ERA in four career matchups with the Royals.
Jordan Schafer was 2 for 2 for the Twins on Saturday and is batting .321 in 10 games since being acquired from the Braves, for whom he had hit .163 over 63 contests.