He'll also try to help the Giants regain sole possession of the NL West lead while continuing his success at home against the Colorado Rockies on Saturday.
Cain was honored before Friday's series opener with a plaque commemorating his perfect game on June 13, the first in Giants' history. That victory at AT&T Park over Houston was one of eight consecutive winning starts for the right-hander, but he's 1-3 with a 4.30 ERA in his last eight starts.
Cain (10-5, 3.01 ERA) is also 0-2 with a 5.26 ERA since a 3-2 win over the Astros on July 15 and endured one of his worst outings of the season Monday in St. Louis, giving up five runs over 5 2-3 innings of an 8-2 loss.
"I'm going out there to try and do my job. There's times you give up maybe more pitches in different games. I guess it's just make better pitches and get quicker outs," he told the team's website.
Cain is 3-0 with a 1.50 ERA in his last four home games against the Rockies (41-69) and has recorded wins in the past two overall matchups, the most recent coming Sept. 18. The right-hander, though, will need more runs from his teammates than they produced in Friday's series opener if he wants to earn another victory.
After a 5-2 road trip that included a three-game sweep of Colorado, the Giants (61-52) had only three hits in a 3-0 defeat, their eighth in nine home games. That loss, coupled with Los Angeles' 5-2 win in Miami earlier in the evening, dropped San Francisco into a tie for first with the Dodgers.
The Giants have been shut out five times at AT&T Park and six times overall. They're batting .195 and have been outscored 48-19 over their last nine home games.
"We go into every game with the same amount of confidence and it doesn't matter where we're playing,'' said shortstop Brandon Crawford, who had two of San Francisco's three hits. "We just haven't seemed to get hits here lately."
The win, meanwhile, helped the Rockies improve to 3-1 on their six-game trip, and Drew Pomeranz (1-6, 4.76) will try to lead his team to another victory by building on one of his better outings of the year.
The left-hander struck out a career-high seven in a 2-0 victory at the Los Angeles Dodgers on Monday but needed 84 pitches to get through four innings. He was 0-3 with a 9.35 ERA over his previous four starts.
"My mechanics weren't the greatest, but I made it work and gave it everything I had," Pomeranz told the team's website. "I wish I had thrown a few less pitches, but it happens."
Pomeranz will face the Giants for the first time this season and is 1-0 with a 3.97 ERA in two career starts against them. He gave up three runs and six hits over 5 2-3 innings during his only game in San Francisco, a 6-3 win Sept. 28.
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- Colorado Rockies