A pair of former All-Star shortstops might be back in their respective lineups at Chavez Ravine.
The Los Angeles Dodgers are hoping Hanley Ramirez will have the greater impact.
Ramirez could make his first start of the season Tuesday night while Troy Tulowitzki is likely to return for the Colorado Rockies.
Ramirez started the season on the disabled list with a torn ligament in his right thumb suffered during the championship game of the World Baseball Classic. He was activated Monday and struck out in a pinch-hit appearance in a 12-2 loss to the Rockies (16-10).
"I'm ready to go," said Ramirez, who will wear a splint on his thumb. "It's not 100 percent, but I can defend myself on the field. I just want to be in there. I don't want to wait any longer. I think I can play."
Los Angeles (12-13) may be hoping for a jolt of offense from Ramirez since it's hitting .198 over the past six games.
Ramirez, a three-time All-Star, hit .271 with 10 homers and 44 RBIs in 64 games after the Dodgers acquired him from Miami in a four-player trade in July.
He's batting .354 with 10 runs and five stolen bases over his last 13 meetings with the Rockies, who may welcome back Tulowitzki after he sat out Monday's game.
Tulowitzki hurt his shoulder on an awkward slide into home in the first inning of Sunday's 4-2 loss at Arizona.
The two-time All-Star has a .308 average with six homers and a team-high 22 RBIs, though he doesn't have one in his last five matchups with Los Angeles while going 3 for 20.
The Rockies didn't seem to miss Tulowitzki while turning in their best offensive showing of the year Monday. Their 19 hits were a season high and included three homers.
"That was impressive. It was just what the doctor ordered," manager Walt Weiss said.
Colorado's 35 home runs are tied with the New York Yankees for second in the majors, one back of Atlanta.
Jorge De La Rosa (2-2, 2.86 ERA) is scheduled to take the mound in search of his first win over the Dodgers.
The left-hander is 0-7 with a 6.22 ERA in 13 games against them, including nine starts. He's 0-3 in five starts at Chavez Ravine despite a 2.49 ERA, having been backed by just five total runs.
De La Rosa has been pretty reliable of late. He's gone six innings in four consecutive starts, allowing a combined five earned runs.
The Dodgers turn to rookie Hyun-Jin Ryu (2-1, 3.41), who is facing the Rockies for the first time while trying to build on his longest and best start of the season.
The South Korean left-hander allowed one run and three hits in seven innings while not getting a decision in Thursday's 3-2 road win over the New York Mets.
Ryu is taking the mound at home for the first time since April 7, when he yielded two runs and three hits in 6 1-3 innings of a 6-2 win over Pittsburgh.