SAN DIEGO -- Charlie Blackmon had two hits and drove in two runs, and the Colorado Rockies earned a 5-4 victory over the San Diego Padres before 19,411 fans at Petco Park on Wednesday night.
The Rockies, who took two of three in the series, are 10-3 this season against the Padres, who lost for the 11th time in 12 games.
Jorge De La Rosa worked five-plus innings, allowing two runs on two hits with four walks and four strikeouts. De La Rosa (9-5) pitched four strong innings before struggling in the fifth and sixth. Two of his walks occurred in the fifth, and he issued a pass to Chase Headley in the sixth before slugger Carlos Quentin followed with his 11th home run of the season.
Closer Rafael Betancourt gave up a run in the ninth before retiring Quentin for his 13th save.
Padres starter Andrew Cashner (5-5) gave up three runs (two earned) on eight hits in five innings. He struck out five and walked two.
The Rockies (44-48) held a 4-0 lead after Herrera scored on a single by Blackmon in the sixth. However, San Diego rallied.
Quentin chased De La Rosa by driving a 1-1 pitch over the wall in center for a two-run homer to cut the lead in half with no outs in the sixth.
The Padres (41-51) sliced the lead to 4-3 when Chris Denorfia drove in Everth Cabrera with no outs in the seventh.
Blackmon smoked an eighth-inning triple into the right field corner, scoring pinch hitter Corey Dickerson, to boost Colorado's lead to 5-3.
Todd Helton drew a leadoff walk in the second inning and scored on Jonathan Herrera's sacrifice fly, putting the Rockies on top 1-0.
Helton's RBI single with two outs in the third plated DJ LeMahieu for a 2-0 advantage.
In the fifth, the Rockies made it 3-0 when LeMahieu, who reached on an error, scored on a wild pitch.
NOTES: OF Dexter Fowler and SS Troy Tulowitzki will rejoin the Rockies on Thursday in Los Angeles, where the club opens a four-game series with the Dodgers. Fowler, who has been out since June 26 with a bone bruise in his right hand, could be in the lineup Thursday, but Tulowitzki will be re-evaluated, manager Walt Weiss said Wednesday. Tulowitzki has been on the disabled list since June 14 with a fractured rib. ... Rockies OF Carlos Gonzalez returned to the lineup after missing two games with an injury to his right middle finger. ... RHP Sean O'Sullivan will be called up from Triple-A Tucson to start for the Padres on Friday against the San Francisco Giants. O'Sullivan has a 7-4 record with a 3.88 ERA in 18 starts with Tucson.