The NCAA has investigated Syracuse's basketball program for years and the school has received a letter of preliminary inquiry, according to CBSSports.com.
The specifics of the violations, which are considered major, were not revealed in the report. The probe is believed to include football but to a lesser extent than basketball.
The NCAA declined to confirm the investigation.
"We can't comment on current, pending or potential legislation," NCAA spokeswoman Emily Potter told CBSSports.com.
Last year, Syracuse acknowledged an NCAA inquiry into possible violations of its drug policy, which was first reported by Yahoo! Sports.
"As we said last year at this time, we are collaborating with the NCAA as part of an ongoing inquiry," Kevin Quinn, Syracuse senior vice president for public affairs, told CBSSports.com. "Given this process is ongoing, we are unable to comment further at this time."
Syracuse opens NCAA tournament play on Thursday against Montana in San Jose, Calif., as the No. 4 seed in the East Regional.