Marrone led Syracuse to an 8-5 record this season, including a strong finish this year that ended with a victory over West Virginia in the Pinstripe Bowl.
The Bills had interviewed Chip Kelly and Lovie Smith as well before deciding on Marrone.
Buffalo is 16-32 in the past three seasons under Chan Gailey, who was fired on Monday.
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This story originally appeared on Nationalfootballpost.com