CINCINNATI -- Cincinnati Reds right-hander Homer Bailey now owns the last two no-hitters in the major leagues.
Bailey, who had a perfect game through six innings Tuesday night, finished with the 16th no-hitter in franchise history, striking out nine in a 3-0 victory over the San Francisco Giants at Great American Ball Park.
Second baseman Brandon Phillips gave Bailey some breathing room with a two-run home run in the sixth.
Bailey also threw a no-hitter against the Pittsburgh Pirates at PNC Park on Sept. 28, 2012. Nolan Ryan was the last pitcher to be responsible for the last two no-hitters in the majors, accomplishing the feat in 1974 and '75.
With the crowd of 27,509 standing in the ninth inning, Bailey retired Brandon Crawford on a ground ball back to the mound, then struck out pinch hitter Tony Abreu swinging. He got Blanco to ground to third baseman Todd Frazier to end it.
Bailey threw 109 pitches, 74 of them strikes.
It was the first no-hitter pitched in Cincinnati since Tom Browning's perfect game against the Los Angeles Dodgers on Sept. 16, 1988.
Bailey (5-6) retired the first 18 batters he faced before Blanco walked on a 3-2 pitch to begin the seventh.
First baseman Joey Votto might have saved Bailey's no-hitter in the seventh when he fielded Buster Posey's slow roller, and when it appeared Bailey wasn't going to cover first base in time, instead threw to third to retire Blanco on a fielder's choice. Pablo Sandoval struck out to end the inning.
Bailey struck out three straight batters in the sixth. He went to 3-2 on Brandon Crawford in that inning, which was just his third full count to that point.
Giants starter Tim Lincecum kept it a one-run game until the sixth when Votto singled and Phillips followed with a line drive home run to left, making the score 3-0.
Lincecum (4-9) allowed three runs over 5 1/3 innings.
In the first inning, Shin-Soo Choo doubled off Hunter Pence's glove in right and later scored on a sacrifice fly by Joey Votto, putting Cincinnati ahead 1-0.
Choo's hit initially was ruled a homer, but after a two-minute, 15-second review, the umpires concluded the ball caromed off Pence's glove and did not clear the fence.
The closest the Giants came to a hit through six innings was on Pablo Sandoval's fifth-inning grounder. Shortstop Zack Cozart ranged far to his left to field the ball behind second base, and he threw out Sandoval at first.
NOTES: Giants LHP Mike Kickham, who allowed seven earned runs in 2 2/3 innings Monday night, was moved to the bullpen, where he'll assume a long-relief role. Kickham is 0-3 with a 13.94 ERA in three starts. .. Reds LF Ryan Ludwick, on the disabled list since suffering a shoulder injury on Opening Day, has resumed baseball activity, including hitting off a tee. .. Giants INF Joaquin Arias, who hadn't played since straining his left hamstring on June 24, was available to pinch-hit Tuesday. Arias further tested his hamstring before the game and is closer to returning to the starting lineup. .. From June 1 through July 1, San Francisco averaged 3.25 runs per game, second fewest in the major leagues behind the Houston Astros in that span. "We're expanding too much," Giants manager Bruce Bochy said. "It's human nature. They all want to be the guy who carries us and gets us out of it. That's not the way it works."