CINCINNATI -- Cesar Izturis' RBI single drove home Jay Bruce with the winning run capping a three-run 13th inning as the Cincinnati Reds rallied for a dramatic 5-4 victory over the Chicago Cubs in the opener of a three-game series at Great American Ball Park.
Luis Valbuena's two-run home run off Alfredo Simon gave the Cubs a brief 4-2 lead in the 13th inning.
But, in the bottom of the inning, Bruce, who hit his first home run of the season in the seventh inning, lined a two-run double off Michael Bowden to tie the score. Bowden (0-1) took the loss.
Carlos Marmol had not allowed a run in five appearances since being removed from the Cubs' closer's role. He pitched two scoreless innings Monday night, including striking out Joey Votto with the winning run at third to end the 10th inning.
Chicago had the bases loaded with two outs in the 11th, but Starlin Castro lined to right on a 3-2 pitch from J.J. Hoover.
Cubs centerfielder David DeJesus led off the game with his third home run.
Reds leadoff batter Shin-Soo Choo reached base for the 19th straight appearance and was hit by a pitch for the 10th time in April, setting a new franchise record for a month.
The Cubs, who entered Monday's game ranked second in the majors with 17 errors, were solid defensively Monday night, highlighted by Castro's diving grab of Chris Heisey's line drive in the fifth inning.
Cubs starter Travis Wood allowed just two hits through six inning against his former club. But things unraveled for Wood and the Cubs in the seventh.
Bruce launched an 0-1 pitch from Wood into the right-center field seats reducing Cincinnati's deficit to 2-1.
Heisey then legged out an infield single, advanced to second on a balk by Shawn Camp, and scored the tying run on Jack Hannahan's pinch-hit triple off James Russell.
Cincinnati starter Mike Leake needed 108 pitches to get through seven innings. He gave up two earned runs while allowing eight hits.
With the score tied 2-2, Reds closer Aroldis Chapman pitched the ninth and struck out all three batters he faced.
Reds right-hander Jonathan Broxton left the game in the eighth inning after being struck on the right hand by a Nate Schierholtz line drive. X-rays were negative.
Cubs batters struck out 10 times, giving Reds pitchers at least 10 strikeouts in five straight games for the first time since 1900.
DeJesus' lead-off homer was his 13th career leadoff home run.
Leake retired the next six batters, with three of those outs coming on strikeouts.
Castro extended his hitting streak to 14 games with an RBI single in the third inning, putting the Cubs ahead 2-0.
Wood retired the first seven batters he faced before Devin Mesoraco's single in the third.
NOTES: Reds left-handed pitcher Sean Marshall, who's been on the disabled list since April 10 with left shoulder tendinitis, made his first rehab start for Triple-A Louisville Monday night, throwing 12 pitches in a 1-2-3 first inning and striking out two. .. Cubs right-hander Matt Garza plans to make a rehab start on Wednesday for Double-A Tennessee. Garza is expected to throw 45 to 50 pitches. He missed all of Spring Training with a strained left lat muscle. .. Castro's 14-game hitting streak is the longest of his career and is the longest active streak in the majors.